Co-Stimulatory versus Cell Death Aspects of Agonistic CD40 Monoclonal Antibody Selicrelumab in Chronic Lymphocytic Leukemia

SIMPLE SUMMARY: Previous observations have shown that CD40 activation of CLL cells via coculture with CD40L-expressing fibroblasts increases sensitivity to cell death by CD20 mAbs rituximab and obinutuzumab. We studied the activity of the fully human-agonistic CD40 mAb selicrelumab in primary CLL ce...

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Detalles Bibliográficos
Autores principales: Delgado, Raquel, Kielbassa, Karoline, ter Burg, Johanna, Klein, Christian, Trumpfheller, Christine, de Heer, Koen, Kater, Arnon P., Eldering, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234015/
https://www.ncbi.nlm.nih.gov/pubmed/34205588
http://dx.doi.org/10.3390/cancers13123084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234015/
https://www.ncbi.nlm.nih.gov/pubmed/34205588
http://dx.doi.org/10.3390/cancers13123084

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