TAT-Conjugated NDUFS8 Can Be Transduced into Mitochondria in a Membrane-Potential-Independent Manner and Rescue Complex I Deficiency

NADH dehydrogenase (ubiquinone) Fe-S protein 8 (NDUFS8) is a nuclear-encoded core subunit of human mitochondrial complex I. Defects in NDUFS8 are associated with Leigh syndrome and encephalomyopathy. Cell-penetrating peptide derived from the HIV-1 transactivator of transcription protein (TAT) has be...

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Detalles Bibliográficos
Autores principales: Lin, Bo-Yu, Zheng, Gui-Teng, Teng, Kai-Wen, Chang, Juan-Yu, Lee, Chao-Chang, Liao, Pin-Chao, Kao, Mou-Chieh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234171/
https://www.ncbi.nlm.nih.gov/pubmed/34204592
http://dx.doi.org/10.3390/ijms22126524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234171/
https://www.ncbi.nlm.nih.gov/pubmed/34204592
http://dx.doi.org/10.3390/ijms22126524

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