Cargando…

TAT-Conjugated NDUFS8 Can Be Transduced into Mitochondria in a Membrane-Potential-Independent Manner and Rescue Complex I Deficiency

NADH dehydrogenase (ubiquinone) Fe-S protein 8 (NDUFS8) is a nuclear-encoded core subunit of human mitochondrial complex I. Defects in NDUFS8 are associated with Leigh syndrome and encephalomyopathy. Cell-penetrating peptide derived from the HIV-1 transactivator of transcription protein (TAT) has be...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Bo-Yu, Zheng, Gui-Teng, Teng, Kai-Wen, Chang, Juan-Yu, Lee, Chao-Chang, Liao, Pin-Chao, Kao, Mou-Chieh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234171/ https://www.ncbi.nlm.nih.gov/pubmed/34204592 http://dx.doi.org/10.3390/ijms22126524

Ejemplares similares

The opposite prognostic effect of NDUFS1 and NDUFS8 in lung cancer reflects the oncojanus role of mitochondrial complex I
por: Su, Chia-Yi, et al.
Publicado: (2016)

IQGAP1 mediates the communication between the nucleus and the mitochondria via NDUFS4 alternative splicing
por: Papadaki, Vasiliki, et al.
Publicado: (2023)

Double administration of self-complementary AAV9(NDUFS4) prevents Leigh disease in Ndufs4(−/−) mice
por: Corrà, Samantha, et al.
Publicado: (2022)

A Single Intravenous Injection of AAV-PHP.B-hNDUFS4 Ameliorates the Phenotype of Ndufs4(−/−) Mice
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2020)

TatBC-Independent TatA/Tat Substrate Interactions Contribute to Transport Efficiency
por: Taubert, Johannes, et al.
Publicado: (2015)

Blockade of monocyte-endothelial trafficking by transduced Tat-superoxide dismutase protein
por: PARK, SIN-HYE, et al.
Publicado: (2016)

NDUFS4 Regulates Cristae Remodeling in Diabetic Kidney Disease
por: Mise, Koki, et al.
Publicado: (2023)

Ndufs4 ablation decreases synaptophysin expression in hippocampus
por: Shil, Subrata Kumar, et al.
Publicado: (2021)

Mitochondrial Ultrastructural Defects in NDUFS3-Related Disorder
por: Samanta, Debopam, et al.
Publicado: (2021)

Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner
por: Li, Tianpeng, et al.
Publicado: (2015)

Emerging Roles of NDUFS8 Located in Mitochondrial Complex I in Different Diseases
por: Wang, Sifan, et al.
Publicado: (2022)

HIV-1 Tat, apoptosis and the mitochondria: a tubulin link?
por: Giacca, Mauro
Publicado: (2005)

Transduced Tat-CIAPIN1 reduces the inflammatory response on LPS− and TPA-induced damages
por: Yeo, Hyeon Ji, et al.
Publicado: (2019)

The TAT-RasGAP(317-326) anti-cancer peptide can kill in a caspase-, apoptosis-, and necroptosis-independent manner
por: Heulot, Mathieu, et al.
Publicado: (2016)

Mutations in NDUFS1 Cause Metabolic Reprogramming and Disruption of the Electron Transfer
por: Ni, Yang, et al.
Publicado: (2019)

Ndufs4 knockout mouse models of Leigh syndrome: pathophysiology and intervention
por: van de Wal, Melissa A E, et al.
Publicado: (2021)

Expansion of the clinical and neuroimaging spectrum associated with NDUFS8‐related disorder
por: Andzelm, Milena M., et al.
Publicado: (2022)

LEVERAGING THE NDUFS4-/- MOUSE AS A PLATFORM FOR TESTING LONGEVITY INTERVENTIONS
por: Bitto, Alessandro, et al.
Publicado: (2022)

Mitochondrial targeting of human NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy
por: Liu, Hsin-Yu, et al.
Publicado: (2011)

Protective effects of transduced Tat-DJ-1 protein against oxidative stress and ischemic brain injury
por: Jeong, Hoon Jae, et al.
Publicado: (2012)

Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage
por: Cho, Su Bin, et al.
Publicado: (2019)

Fates of Sec, Tat, and YidC Translocases in Mitochondria and Other Eukaryotic Compartments
por: Petrů, Markéta, et al.
Publicado: (2021)

Depicting Binding-Mediated Translocation of HIV-1 Tat Peptides in Living Cells with Nanoscale Pens of Tat-Conjugated Quantum Dots
por: Lin, Chien Y., et al.
Publicado: (2017)

Replication fork rescue in mammalian mitochondria
por: Torregrosa-Muñumer, Rubén, et al.
Publicado: (2019)

Conjugation to the Cell-Penetrating Peptide TAT Potentiates the Photodynamic Effect of Carboxytetramethylrhodamine
por: Srinivasan, Divyamani, et al.
Publicado: (2011)

Region-Specific Defects of Respiratory Capacities in the Ndufs4(KO) Mouse Brain
por: Kayser, Ernst-Bernhard, et al.
Publicado: (2016)

Adult mesenchymal stem cell ageing interplays with depressed mitochondrial Ndufs6
por: Zhang, Yuelin, et al.
Publicado: (2020)

Peripheral macrophages drive CNS disease in the Ndufs4(−/−) model of Leigh syndrome
por: Hanaford, Allison R., et al.
Publicado: (2023)

NDUFB11 and NDUFS3 play a role in atherosclerosis and chronic stress
por: Yang, Yin, et al.
Publicado: (2023)

TAT-PEP Alleviated Cognitive Impairment by Alleviating Neuronal Mitochondria Damage and Apoptosis After Cerebral Ischemic Reperfusion Injury
por: Zhao, Pin, et al.
Publicado: (2023)

Unanticipated functional diversity among the TatA-type components of the Tat protein translocase
por: Eimer, Ekaterina, et al.
Publicado: (2018)

Transduced Tat-DJ-1 protein inhibits cytokines-induced pancreatic RINm5F cell death
por: Jo, Hyo Sang, et al.
Publicado: (2016)

SBDS(R126T) rescues survival of sbds(−/−) zebrafish in a dose-dependent manner independently of Tp53
por: Oyarbide, Usua, et al.
Publicado: (2023)

Evolution of mitochondrial TAT translocases illustrates the loss of bacterial protein transport machines in mitochondria
por: Petrů, Markéta, et al.
Publicado: (2018)

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy
por: Bourke, Lauren T, et al.
Publicado: (2013)

Enhanced Cellular Entry and Efficacy of Tat Conjugates by Rational Design of the Auxiliary Segment
por: Zhang, Pengcheng, et al.
Publicado: (2014)

Examining the Cellular Transport Pathway of Fusogenic Quantum Dots Conjugated With Tat Peptide
por: Dai, Jie, et al.
Publicado: (2022)

Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells
por: Suhane, Sonal, et al.
Publicado: (2013)

NDUFAF7 Methylates Arginine 85 in the NDUFS2 Subunit of Human Complex I
por: Rhein, Virginie F., et al.
Publicado: (2013)

NDUFAF5 Hydroxylates NDUFS7 at an Early Stage in the Assembly of Human Complex I
por: Rhein, Virginie F., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_n9kq51ded4mcduiiivvr98kov7