In Vitro Inhibition of Renal OCT2 and MATE1 Secretion by Antiemetic Drugs

The organic cation transporter 2 (OCT2) and multidrug and toxin extrusion protein 1 (MATE1) mediate the renal secretion of drugs. Recent studies suggest that ondansetron, a 5-HT(3) antagonist drug used to prevent nausea and vomiting, can inhibit OCT2- and MATE1-mediated transport. The purpose of thi...

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Detalles Bibliográficos
Autores principales: George, Blessy, Wen, Xia, Jaimes, Edgar A., Joy, Melanie S., Aleksunes, Lauren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234231/
https://www.ncbi.nlm.nih.gov/pubmed/34208557
http://dx.doi.org/10.3390/ijms22126439

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234231/
https://www.ncbi.nlm.nih.gov/pubmed/34208557
http://dx.doi.org/10.3390/ijms22126439

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