HDAC Inhibitor Abrogates LTA−Induced PAI-1 Expression in Pleural Mesothelial Cells and Attenuates Experimental Pleural Fibrosis

Lipoteichoic acid (LTA) stimulates pleural mesothelial cell (PMC) to overproduce plasminogen activator inhibitor-1 (PAI-1), and thus may promote pleural fibrosis in Gram-positive bacteria (GPB) parapneumonic effusion (PPE). Histone deacetylase inhibitor (HDACi) was found to possess anti-fibrotic pro...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Lin, Chen, Mei-Chuan, Hsu, Shang-Fu, Hsiao, Shih-Hsin, Chung, Chi-Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234320/
https://www.ncbi.nlm.nih.gov/pubmed/34207271
http://dx.doi.org/10.3390/ph14060585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234320/
https://www.ncbi.nlm.nih.gov/pubmed/34207271
http://dx.doi.org/10.3390/ph14060585

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