Natural Alkaloid Compounds as Inhibitors for Alpha-Synuclein Seeded Fibril Formation and Toxicity

The accumulation and aggregation of α-synuclein (α-syn) is the main pathologic event in Parkinson’s disease (PD), dementia with Lewy bodies, and multiple system atrophy. α-Syn-seeded fibril formation and its induced toxicity occupy a major role in PD pathogenesis. Thus, assessing compounds that inhi...

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Detalles Bibliográficos
Autores principales: Ghanem, Simona S., Fayed, Hend S., Zhu, Qi, Lu, Jia-Hong, Vaikath, Nishant N., Ponraj, Janarthanan, Mansour, Said, El-Agnaf, Omar M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234408/
https://www.ncbi.nlm.nih.gov/pubmed/34205249
http://dx.doi.org/10.3390/molecules26123736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234408/
https://www.ncbi.nlm.nih.gov/pubmed/34205249
http://dx.doi.org/10.3390/molecules26123736

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