Cargando…
Multiscale Models for Fibril Formation: Rare Events Methods, Microkinetic Models, and Population Balances
Amyloid fibrils are thought to grow by a two-step dock-lock mechanism. However, previous simulations of fibril formation (i) overlook the bi-molecular nature of the docking step and obtain rates with first-order units, or (ii) superimpose the docked and locked states when computing the potential of...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234428/ https://www.ncbi.nlm.nih.gov/pubmed/34204410 http://dx.doi.org/10.3390/life11060570 |