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Combined Mutational and Clonality Analyses Support the Existence of Intra-Tumor Heterogeneity in Papillary Thyroid Cancer

Despite its potential clinical impact, intra-tumor genetic heterogeneity (ITH) has been scantly investigated in papillary thyroid cancer (PTC). We studied ITH in PTC by combining, for the first time, data derived from the evaluation of the normalized allelic frequencies (NAF) of the mutation/s, usin...

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Detalles Bibliográficos
Autores principales: Muzza, Marina, Pogliaghi, Gabriele, Persani, Luca, Fugazzola, Laura, Colombo, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234519/
https://www.ncbi.nlm.nih.gov/pubmed/34208446
http://dx.doi.org/10.3390/jcm10122645