LABRAT reveals association of alternative polyadenylation with transcript localization, RNA binding protein expression, transcription speed, and cancer survival

BACKGROUND: The sequence content of the 3′ UTRs of many mRNA transcripts is regulated through alternative polyadenylation (APA). The study of this process using RNAseq data, though, has been historically challenging. RESULTS: To combat this problem, we developed LABRAT, an APA isoform quantification...

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Detalles Bibliográficos
Autores principales: Goering, Raeann, Engel, Krysta L., Gillen, Austin E., Fong, Nova, Bentley, David L., Taliaferro, J. Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234626/
https://www.ncbi.nlm.nih.gov/pubmed/34174817
http://dx.doi.org/10.1186/s12864-021-07781-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234626/
https://www.ncbi.nlm.nih.gov/pubmed/34174817
http://dx.doi.org/10.1186/s12864-021-07781-1

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