Pharmacokinetics and Molecular Modeling Indicate nAChRα4-Derived Peptide HAEE Goes through the Blood–Brain Barrier

One of the treatment strategies for Alzheimer’s disease (AD) is based on the use of pharmacological agents capable of binding to beta-amyloid (Aβ) and blocking its aggregation in the brain. Previously, we found that intravenous administration of the synthetic tetrapeptide Acetyl-His-Ala-Glu-Glu-Amid...

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Detalles Bibliográficos
Autores principales: Zolotarev, Yurii A., Mitkevich, Vladimir A., Shram, Stanislav I., Adzhubei, Alexei A., Tolstova, Anna P., Talibov, Oleg B., Dadayan, Alexander K., Myasoyedov, Nikolai F., Makarov, Alexander A., Kozin, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234734/
https://www.ncbi.nlm.nih.gov/pubmed/34207317
http://dx.doi.org/10.3390/biom11060909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234734/
https://www.ncbi.nlm.nih.gov/pubmed/34207317
http://dx.doi.org/10.3390/biom11060909

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