The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells

We recently found that, in human osteoblasts, Homer1 complexes to Calcium-sensing receptor (CaSR) and mediates AKT initiation via mechanistic target of rapamycin complex (mTOR) complex 2 (mTORC2) leading to beneficial effects in osteoblasts including β-catenin stabilization and mTOR complex 1 (mTORC...

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Detalles Bibliográficos
Autores principales: Rybchyn, Mark S., Brennan-Speranza, Tara Clare, Mor, David, Cheng, Zhiqiang, Chang, Wenhan, Conigrave, Arthur D., Mason, Rebecca S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234890/
https://www.ncbi.nlm.nih.gov/pubmed/34204449
http://dx.doi.org/10.3390/ijms22126509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234890/
https://www.ncbi.nlm.nih.gov/pubmed/34204449
http://dx.doi.org/10.3390/ijms22126509

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