Cargando…

The mTORC2 Regulator Homer1 Modulates Protein Levels and Sub-Cellular Localization of the CaSR in Osteoblast-Lineage Cells

We recently found that, in human osteoblasts, Homer1 complexes to Calcium-sensing receptor (CaSR) and mediates AKT initiation via mechanistic target of rapamycin complex (mTOR) complex 2 (mTORC2) leading to beneficial effects in osteoblasts including β-catenin stabilization and mTOR complex 1 (mTORC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rybchyn, Mark S., Brennan-Speranza, Tara Clare, Mor, David, Cheng, Zhiqiang, Chang, Wenhan, Conigrave, Arthur D., Mason, Rebecca S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8234890/ https://www.ncbi.nlm.nih.gov/pubmed/34204449 http://dx.doi.org/10.3390/ijms22126509

Ejemplares similares

UV‐induced DNA Damage in Skin is Reduced by CaSR Inhibition
por: Yang, Chen, et al.
Publicado: (2022)

Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways
por: Gong, Yulong, et al.
Publicado: (2023)

The CaSR Modulator NPS-2143 Reduced UV-Induced DNA Damage in Skh:hr1 Hairless Mice but Minimally Inhibited Skin Tumours
por: Yang, Chen, et al.
Publicado: (2023)

Calcium-sensing receptor (CaSR) as a novel target for ischemic neuroprotection
por: Kim, Jong Youl, et al.
Publicado: (2014)

mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells
por: Schaub, Theres, et al.
Publicado: (2019)

mTORC1 Signaling Promotes Osteoblast Differentiation from Preosteoblasts
por: Chen, Jianquan, et al.
Publicado: (2015)

Physiological studies in heterozygous calcium sensing receptor (CaSR) gene-ablated mice confirm that the CaSR regulates calcitonin release in vivo
por: Fudge, Neva J, et al.
Publicado: (2004)

SUN-266 Protein Induced Pancreatic Hormone Secretion Is Modulated by Vagal CaSR
por: Norton, Mariana, et al.
Publicado: (2020)

mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
por: Martin, Sally K., et al.
Publicado: (2018)

Publisher Correction: mTORC1 and mTORC2 Differentially Regulate Cell Fate Programs to Coordinate Osteoblastic Differentiation in Mesenchymal Stromal Cells
por: Schaub, Theres, et al.
Publicado: (2020)

OR11-003 - The NLRP3 inflammasome is regulated by CaSR
por: Chae, JJ, et al.
Publicado: (2013)

ERK signaling mediates CaSR-promoted axon growth
por: Vizard, Thomas N., et al.
Publicado: (2015)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

mTORC1 activity is essential for erythropoiesis and B cell lineage commitment
por: Malik, Natasha, et al.
Publicado: (2019)

Glucose‐loading reduces bone remodeling in women and osteoblast function in vitro
por: Levinger, Itamar, et al.
Publicado: (2016)

Rescue of High Glucose Impairment of Cultured Human Osteoblasts Using Cinacalcet and Parathyroid Hormone
por: Shahen, V. A., et al.
Publicado: (2023)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

An Unusual Case of Meningioma Showing Increased CaSR Expression with Parathyroid Carcinoma
por: Yoo, Jin Sae, et al.
Publicado: (2018)

Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications
por: Joseph, Naomi, et al.
Publicado: (2019)

CaSR Induces Osteoclast Differentiation and Promotes Bone Metastasis in Lung Adenocarcinoma
por: Liu, Lian, et al.
Publicado: (2020)

Calcium-Sensing Receptor (CaSR)-Mediated Intracellular Communication in Cardiovascular Diseases
por: Chu, Hezhen, et al.
Publicado: (2022)

Phenylalanine promotes alveolar macrophage pyroptosis via the activation of CaSR in ARDS
por: Tang, Yiding, et al.
Publicado: (2023)

Is it reasonable to ignore vitamin D status for musculoskeletal health?
por: Mason, Rebecca S, et al.
Publicado: (2020)

SAT-350 A Tale of Two Mutations: Familial Hypocalciuric Hypercalcemia Caused by a Novel CaSR Start Codon Mutation Found in the Setting of a CaSR Hypercalciuric Variant
por: Bandaru, Sindhura, et al.
Publicado: (2020)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

The mTORC1 complex in pre-osteoblasts regulates whole-body energy metabolism independently of osteocalcin
por: Tangseefa, Pawanrat, et al.
Publicado: (2021)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

mTORC2 orchestrates monocytic and granulocytic lineage commitment by an ATF5-mediated pathway
por: Zhao, Yang, et al.
Publicado: (2023)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Ca(2+)/Sr(2+) Selectivity in Calcium-Sensing Receptor (CaSR): Implications for Strontium’s Anti-Osteoporosis Effect
por: Cheshmedzhieva, Diana, et al.
Publicado: (2021)

Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury
por: Zhai, Tai-yu, et al.
Publicado: (2021)

Calcium-Sensing Receptor (CaSR), Its Impact on Inflammation and the Consequences on Cardiovascular Health
por: Sundararaman, Sai Sahana, et al.
Publicado: (2021)

Effects of Sodium Ferulate on Cardiac Hypertrophy Are via the CaSR-Mediated Signaling Pathway
por: Chen, Panpan, et al.
Publicado: (2021)

Aberrant upregulation of CaSR promotes pathological new bone formation in ankylosing spondylitis
por: Li, Xiang, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_72csdbij31b89310dl0507et80