Effective Tumor Targeting by EphA2-Agonist-Biotin-Streptavidin Conjugates

We recently reported on a potent synthetic agent, 135H11, that selectively targets the receptor tyrosine kinase, EphA2. While 135H11 possesses a relatively high binding affinity for the ligand-binding domain of EphA2 (Kd~130 nM), receptor activation in the cell required the synthesis of dimeric vers...

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Detalles Bibliográficos
Autores principales: Udompholkul, Parima, Baggio, Carlo, Gambini, Luca, Sun, Yu, Zhao, Ming, Hoffman, Robert M., Pellecchia, Maurizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235110/
https://www.ncbi.nlm.nih.gov/pubmed/34204178
http://dx.doi.org/10.3390/molecules26123687

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235110/
https://www.ncbi.nlm.nih.gov/pubmed/34204178
http://dx.doi.org/10.3390/molecules26123687

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