High density bioprocessing of human pluripotent stem cells by metabolic control and in silico modeling

To harness the full potential of human pluripotent stem cells (hPSCs) we combined instrumented stirred tank bioreactor (STBR) technology with the power of in silico process modeling to overcome substantial, hPSC‐specific hurdles toward their mass production. Perfused suspension culture (3D) of matri...

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Detalles Bibliográficos
Autores principales: Manstein, Felix, Ullmann, Kevin, Kropp, Christina, Halloin, Caroline, Triebert, Wiebke, Franke, Annika, Farr, Clara‐Milena, Sahabian, Anais, Haase, Alexandra, Breitkreuz, Yannik, Peitz, Michael, Brüstle, Oliver, Kalies, Stefan, Martin, Ulrich, Olmer, Ruth, Zweigerdt, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Manufacturing for Regenerative Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235132/
https://www.ncbi.nlm.nih.gov/pubmed/33660952
http://dx.doi.org/10.1002/sctm.20-0453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235132/
https://www.ncbi.nlm.nih.gov/pubmed/33660952
http://dx.doi.org/10.1002/sctm.20-0453

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