Myeloid-Specific Acly Deletion Alters Macrophage Phenotype In Vitro and In Vivo without Affecting Tumor Growth

SIMPLE SUMMARY: Tumor cells show different metabolism compared to normal tissue. For instance, they increase ATP-citrate lyase (Acly) expression for increased proliferation. Acly is therefore currently being targeted for cancer therapy. However, targeting this enzyme may have side effects on other c...

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Detalles Bibliográficos
Autores principales: de Goede, Kyra E., Verberk, Sanne G. S., Baardman, Jeroen, Harber, Karl J., van Kooyk, Yvette, de Winther, Menno P. J., Schetters, Sjoerd T. T., Van den Bossche, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235155/
https://www.ncbi.nlm.nih.gov/pubmed/34205266
http://dx.doi.org/10.3390/cancers13123054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235155/
https://www.ncbi.nlm.nih.gov/pubmed/34205266
http://dx.doi.org/10.3390/cancers13123054

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