Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal

Claudin-2 (CLDN2), a tight junctional protein, is involved in the chemoresistance in a three-dimensional spheroid culture model of human lung adenocarcinoma A549 cells. However, the mechanism has not been fully clarified. We found that the knockdown of CLDN2 expression by siRNA in the spheroid reduc...

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Detalles Bibliográficos
Autores principales: Ito, Ayaka, Nasako, Haruka, Akizuki, Risa, Takashina, Yui, Eguchi, Hiroaki, Matsunaga, Toshiyuki, Yoshino, Yuta, Endo, Satoshi, Ikari, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235168/
https://www.ncbi.nlm.nih.gov/pubmed/34205320
http://dx.doi.org/10.3390/ijms22126582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235168/
https://www.ncbi.nlm.nih.gov/pubmed/34205320
http://dx.doi.org/10.3390/ijms22126582

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