Cargando…

Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal

Claudin-2 (CLDN2), a tight junctional protein, is involved in the chemoresistance in a three-dimensional spheroid culture model of human lung adenocarcinoma A549 cells. However, the mechanism has not been fully clarified. We found that the knockdown of CLDN2 expression by siRNA in the spheroid reduc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ito, Ayaka, Nasako, Haruka, Akizuki, Risa, Takashina, Yui, Eguchi, Hiroaki, Matsunaga, Toshiyuki, Yoshino, Yuta, Endo, Satoshi, Ikari, Akira
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235168/ https://www.ncbi.nlm.nih.gov/pubmed/34205320 http://dx.doi.org/10.3390/ijms22126582

Ejemplares similares

Increase in Toxicity of Anticancer Drugs by PMTPV, a Claudin-1-Binding Peptide, Mediated via Down-Regulation of Claudin-1 in Human Lung Adenocarcinoma A549 Cells
por: Nasako, Haruka, et al.
Publicado: (2020)

Increase in Anticancer Drug-Induced Toxicity by Fisetin in Lung Adenocarcinoma A549 Spheroid Cells Mediated by the Reduction of Claudin-2 Expression
por: Eguchi, Hiroaki, et al.
Publicado: (2022)

Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression
por: Eguchi, Hiroaki, et al.
Publicado: (2022)

Down-Regulation of Claudin-2 Expression by Cyanidin-3-Glucoside Enhances Sensitivity to Anticancer Drugs in the Spheroid of Human Lung Adenocarcinoma A549 Cells
por: Eguchi, Hiroaki, et al.
Publicado: (2021)

Kaempferide Enhances Chemosensitivity of Human Lung Adenocarcinoma A549 Cells Mediated by the Decrease in Phosphorylation of Akt and Claudin-2 Expression
por: Eguchi, Hiroaki, et al.
Publicado: (2020)

Increase in resistance to anticancer drugs involves occludin in spheroid culture model of lung adenocarcinoma A549 cells
por: Eguchi, Hiroaki, et al.
Publicado: (2018)

Chrysin enhances anticancer drug-induced toxicity mediated by the reduction of claudin-1 and 11 expression in a spheroid culture model of lung squamous cell carcinoma cells
por: Maruhashi, Ryohei, et al.
Publicado: (2019)

Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells
por: Sonoki, Hiroyuki, et al.
Publicado: (2017)

Upregulation of Claudin-7 Expression by Angiotensin II in Colonic Epithelial Cells of Mice Fed with NaCl-Depleted Diets
por: Takashina, Yui, et al.
Publicado: (2020)

Quercetin Decreases Claudin-2 Expression Mediated by Up-Regulation of microRNA miR-16 in Lung Adenocarcinoma A549 Cells
por: Sonoki, Hiroyuki, et al.
Publicado: (2015)

Chemosensitivity of radioresistant cells in the multicellular spheroids of A549 lung adenocarcinoma
por: Shi, Degang, et al.
Publicado: (2009)

Sodium Citrate Increases Expression and Flux of Mg(2+) Transport Carriers Mediated by Activation of MEK/ERK/c-Fos Pathway in Renal Tubular Epithelial Cells
por: Takashina, Yui, et al.
Publicado: (2018)

Protective Effects of Ethanol Extract of Brazilian Green Propolis and Apigenin against Weak Ultraviolet Ray-B-Induced Barrier Dysfunction via Suppressing Nitric Oxide Production and Mislocalization of Claudin-1 in HaCaT Cells
por: Yoshino, Yuta, et al.
Publicado: (2021)

Reactive Oxygen Species Downregulate Transient Receptor Potential Melastatin 6 Expression Mediated by the Elevation of miR-24-3p in Renal Tubular Epithelial Cells
por: Hirota, Chieko, et al.
Publicado: (2021)

Regulation of Paracellular Fluxes of Amino Acids by Claudin-8 in Normal Mouse Intestinal MCE301 Cells
por: Okamoto, Ema, et al.
Publicado: (2023)

Upregulation of Chemoresistance by Mg(2+) Deficiency through Elevation of ATP Binding Cassette Subfamily B Member 1 Expression in Human Lung Adenocarcinoma A549 Cells
por: Onuma, Saki, et al.
Publicado: (2021)

Up-regulation of claudin-2 expression by aldosterone in colonic epithelial cells of mice fed with NaCl-depleted diets
por: Furukawa, Chisa, et al.
Publicado: (2017)

Rescue of tight junctional localization of a claudin-16 mutant D97S by antimalarial medicine primaquine in Madin-Darby canine kidney cells
por: Marunaka, Kana, et al.
Publicado: (2019)

Targeting claudin‐4 enhances chemosensitivity in breast cancer
por: Luo, Yi, et al.
Publicado: (2020)

Brazilian Green Propolis Rescues Oxidative Stress-Induced Mislocalization of Claudin-1 in Human Keratinocyte-Derived HaCaT Cells
por: Marunaka, Kana, et al.
Publicado: (2019)

Weak Ultraviolet B Enhances the Mislocalization of Claudin-1 Mediated by Nitric Oxide and Peroxynitrite Production in Human Keratinocyte-Derived HaCaT Cells
por: Kobayashi, Mao, et al.
Publicado: (2020)

Chemosensitization by misonidazole in CCNU-treated spheroids and tumours.
por: Durand, R. E., et al.
Publicado: (1987)

Targeting claudin-4 enhances CDDP-chemosensitivity in gastric cancer
por: Nishiguchi, Yukiko, et al.
Publicado: (2019)

Targeting claudin‐4 enhances chemosensitivity of pancreatic ductal carcinomas
por: Sasaki, Takamitsu, et al.
Publicado: (2019)

Cyanidin Increases the Expression of Mg(2+) Transport Carriers Mediated by the Activation of PPARα in Colonic Epithelial MCE301 Cells
por: Takashina, Yui, et al.
Publicado: (2019)

Functional Gene Knockout of NRF2 Increases Chemosensitivity of Human Lung Cancer A549 Cells In Vitro and in a Xenograft Mouse Model
por: Bialk, Pawel, et al.
Publicado: (2018)

Knockdown of CLAUDIN-6 Inhibited Apoptosis and Induced Proliferation of Bovine Cumulus Cells
por: Wang, Wanjie, et al.
Publicado: (2022)

Girdin Knockdown Increases Gemcitabine Chemosensitivity to Pancreatic Cancer by Modulating Autophagy
por: Wang, Sheng, et al.
Publicado: (2021)

PRDM14 mediates chemosensitivity and glycolysis in drug-resistant A549/cisplatin cells and their progenitor A549 human lung adenocarcinoma cells
por: He, Saifei, et al.
Publicado: (2021)

Knockdown of STMN1 enhances osteosarcoma cell chemosensitivity through inhibition of autophagy
por: Wang, Zili, et al.
Publicado: (2017)

Knockdown lncRNA CRNDE enhances temozolomide chemosensitivity by regulating autophagy in glioblastoma
por: Zhao, Zijin, et al.
Publicado: (2021)

Claudin 4 Is Differentially Expressed between Ovarian Cancer Subtypes and Plays a Role in Spheroid Formation
por: Boylan, Kristin L. M., et al.
Publicado: (2011)

Knockdown of lncRNA-XIST enhances the chemosensitivity of NSCLC cells via suppression of autophagy
por: Sun, Wei, et al.
Publicado: (2017)

Knockdown of cullin 4A inhibits growth and increases chemosensitivity in lung cancer cells
por: Hung, Ming‐Szu, et al.
Publicado: (2016)

Knockdown of PDIA6 Inhibits Cell Proliferation and Enhances the Chemosensitivity in Gastric Cancer Cells
por: Yan, Chao, et al.
Publicado: (2020)

Knockdown of TACC3 inhibits tumor cell proliferation and increases chemosensitivity in pancreatic cancer
por: Shi, Saimeng, et al.
Publicado: (2023)

NRF2: The key to tumor- and patient-dependent chemosensitivity in biliary tract cancer?
por: Kiesslich, Tobias, et al.
Publicado: (2019)

Cathepsin A knockdown decreases the proliferation and invasion of A549 lung adenocarcinoma cells
por: Hu, Bo, et al.
Publicado: (2020)

Knockdown of CRAD suppresses the growth and promotes the apoptosis of human lung cancer cells via Claudin 4
por: Cui, Anfang, et al.
Publicado: (2020)

Knockdown of Claudin-19 in the Retinal Pigment Epithelium Is Accompanied by Slowed Phagocytosis and Increased Expression of SQSTM1
por: Liu, Fanfei, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7egu3s1olk57ibaepnpr7hcjjp