The Capacity to Secrete Insulin Is Dose-Dependent to Extremely High Glucose Concentrations: A Key Role for Adenylyl Cyclase

Insulin secretion is widely thought to be maximally stimulated in glucose concentrations of 16.7-to-30 mM (300-to-540 mg/dL). However, insulin secretion is seldom tested in hyperglycemia exceeding these levels despite the Guinness World Record being 147.6 mM (2656 mg/dL). We investigated how islets...

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Detalles Bibliográficos
Autores principales: Gerber, Katherine M., Whitticar, Nicholas B., Rochester, Daniel R., Corbin, Kathryn L., Koch, William J., Nunemaker, Craig S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235240/
https://www.ncbi.nlm.nih.gov/pubmed/34205432
http://dx.doi.org/10.3390/metabo11060401

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235240/
https://www.ncbi.nlm.nih.gov/pubmed/34205432
http://dx.doi.org/10.3390/metabo11060401

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