Concise Synthesis of Both Enantiomers of Pilocarpine

Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of...

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Autores principales: Schmidt, Theresa, Heise, Niels, Merzweiler, Kurt, Deigner, Hans-Peter, Al-Harrasi, Ahmed, Csuk, René
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235342/
https://www.ncbi.nlm.nih.gov/pubmed/34208623
http://dx.doi.org/10.3390/molecules26123676
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author Schmidt, Theresa
Heise, Niels
Merzweiler, Kurt
Deigner, Hans-Peter
Al-Harrasi, Ahmed
Csuk, René
author_facet Schmidt, Theresa
Heise, Niels
Merzweiler, Kurt
Deigner, Hans-Peter
Al-Harrasi, Ahmed
Csuk, René
author_sort Schmidt, Theresa
collection PubMed
description Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of both enantiomers of pilocarpine.
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spelling pubmed-82353422021-06-27 Concise Synthesis of Both Enantiomers of Pilocarpine Schmidt, Theresa Heise, Niels Merzweiler, Kurt Deigner, Hans-Peter Al-Harrasi, Ahmed Csuk, René Molecules Article Furan-2-carboxylic acid was used as a starting material for the synthesis of dehydro-homopilopic acid. Esterification, hydrogenation and enzymatic hydrolysis followed by the reduction of Weinreb amides and a single-step attachment of a 1-methyl-imidazole residue allowed for the concise synthesis of both enantiomers of pilocarpine. MDPI 2021-06-16 /pmc/articles/PMC8235342/ /pubmed/34208623 http://dx.doi.org/10.3390/molecules26123676 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Schmidt, Theresa
Heise, Niels
Merzweiler, Kurt
Deigner, Hans-Peter
Al-Harrasi, Ahmed
Csuk, René
Concise Synthesis of Both Enantiomers of Pilocarpine
title Concise Synthesis of Both Enantiomers of Pilocarpine
title_full Concise Synthesis of Both Enantiomers of Pilocarpine
title_fullStr Concise Synthesis of Both Enantiomers of Pilocarpine
title_full_unstemmed Concise Synthesis of Both Enantiomers of Pilocarpine
title_short Concise Synthesis of Both Enantiomers of Pilocarpine
title_sort concise synthesis of both enantiomers of pilocarpine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235342/
https://www.ncbi.nlm.nih.gov/pubmed/34208623
http://dx.doi.org/10.3390/molecules26123676
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