Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update

Citrate plays a central role in cancer cells’ metabolism and regulation. Derived from mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate lyase into acetyl-CoA and oxaloacetate. The rapid turnover of these molecules in proliferative cancer cells maintains a...

Descripción completa

Detalles Bibliográficos
Autores principales: Icard, Philippe, Coquerel, Antoine, Wu, Zherui, Gligorov, Joseph, Fuks, David, Fournel, Ludovic, Lincet, Hubert, Simula, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235534/
https://www.ncbi.nlm.nih.gov/pubmed/34205414
http://dx.doi.org/10.3390/ijms22126587

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235534/
https://www.ncbi.nlm.nih.gov/pubmed/34205414
http://dx.doi.org/10.3390/ijms22126587

Ejemplares similares