Microsatellite Instability in Colorectal Cancers: Carcinogenesis, Neo-Antigens, Immuno-Resistance and Emerging Therapies

SIMPLE SUMMARY: A deficient mismatch repair system (dMMR) results in microsatellite instability (MSI). The MSI status of a tumor predicts the response to immune checkpoint inhibitors (ICI) that are now approved in patients with dMMR/MSI metastatic colorectal cancers. In addition to the mechanisms th...

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Detalles Bibliográficos
Autores principales: Randrian, Violaine, Evrard, Camille, Tougeron, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235567/
https://www.ncbi.nlm.nih.gov/pubmed/34205397
http://dx.doi.org/10.3390/cancers13123063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235567/
https://www.ncbi.nlm.nih.gov/pubmed/34205397
http://dx.doi.org/10.3390/cancers13123063

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