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Microsatellite Instability in Colorectal Cancers: Carcinogenesis, Neo-Antigens, Immuno-Resistance and Emerging Therapies

SIMPLE SUMMARY: A deficient mismatch repair system (dMMR) results in microsatellite instability (MSI). The MSI status of a tumor predicts the response to immune checkpoint inhibitors (ICI) that are now approved in patients with dMMR/MSI metastatic colorectal cancers. In addition to the mechanisms th...

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Detalles Bibliográficos
Autores principales:	Randrian, Violaine, Evrard, Camille, Tougeron, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235567/ https://www.ncbi.nlm.nih.gov/pubmed/34205397 http://dx.doi.org/10.3390/cancers13123063

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