Development of Bisphosphonate-Conjugated Antibiotics to Overcome Pharmacodynamic Limitations of Local Therapy: Initial Results with Carbamate Linked Sitafloxacin and Tedizolid

The use of local antibiotics to treat bone infections has been questioned due to a lack of clinical efficacy and emerging information about Staphylococcus aureus colonization of the osteocyte-lacuno canalicular network (OLCN). Here we propose bisphosphonate-conjugated antibiotics (BCA) using a “targ...

Descripción completa

Detalles Bibliográficos
Autores principales: Adjei-Sowah, Emmanuela, Peng, Yue, Weeks, Jason, Jonason, Jennifer H., de Mesy Bentley, Karen L., Masters, Elysia, Morita, Yugo, Muthukrishnan, Gowrishankar, Cherian, Philip, Hu, X. Eric, McKenna, Charles E., Ebetino, Frank H., Sun, Shuting, Schwarz, Edward M., Xie, Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235690/
https://www.ncbi.nlm.nih.gov/pubmed/34204351
http://dx.doi.org/10.3390/antibiotics10060732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235690/
https://www.ncbi.nlm.nih.gov/pubmed/34204351
http://dx.doi.org/10.3390/antibiotics10060732

Ejemplares similares