3,3′,5-Triiodothyroacetic acid (TRIAC) induces embryonic ζ-globin expression via thyroid hormone receptor α

The human ζ-globin gene (HBZ) is transcribed in primitive erythroid cells only during the embryonic stages of development. Reactivation of this embryonic globin synthesis would likely alleviate symptoms both in α-thalassemia and sickle-cell disease. However, the molecular mechanisms controlling ζ-gl...

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Detalles Bibliográficos
Autores principales: Chen, Huiqiao, Wang, Zixuan, Yu, Shanhe, Han, Xiao, Deng, Yun, Wang, Fuhui, Chen, Yi, Liu, Xiaohui, Zhou, Jun, Zhu, Jun, Yuan, Hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235803/
https://www.ncbi.nlm.nih.gov/pubmed/34174920
http://dx.doi.org/10.1186/s13045-021-01108-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235803/
https://www.ncbi.nlm.nih.gov/pubmed/34174920
http://dx.doi.org/10.1186/s13045-021-01108-z

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