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Recommendations for designing and analysing multi-arm non-inferiority trials: a review of methodology and current practice

BACKGROUND AND PURPOSE: Multi-arm non-inferiority (MANI) trials, here defined as non-inferiority trials with multiple experimental treatment arms, can be useful in situations where several viable treatments exist for a disease area or for testing different dose schedules. To maintain the statistical...

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Detalles Bibliográficos
Autores principales: Emmerson, Jake, Todd, Susan, Brown, Julia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8235859/
https://www.ncbi.nlm.nih.gov/pubmed/34174937
http://dx.doi.org/10.1186/s13063-021-05364-9