Stepwise gating of the Sec61 protein-conducting channel by Sec63 and Sec62

Many proteins are transported into the endoplasmic reticulum by the universally conserved Sec61 channel. Post-translational transport requires two additional proteins, Sec62 and Sec63, but their functions are poorly defined. Here, we determined cryo-EM structures of several variants of Sec61–Sec62–S...

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Detalles Bibliográficos
Autores principales: Itskanov, Samuel, Kuo, Katie M., Gumbart, James C., Park, Eunyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236211/
https://www.ncbi.nlm.nih.gov/pubmed/33398175
http://dx.doi.org/10.1038/s41594-020-00541-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236211/
https://www.ncbi.nlm.nih.gov/pubmed/33398175
http://dx.doi.org/10.1038/s41594-020-00541-x

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