Role of lung and gut microbiota on lung cancer pathogenesis

BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide (Ferlay et al., Int J Cancer 136:E359–386, 2015). In addition, lung cancer is associated with the highest mortality among all cancer types (Wu et al., Exp Ther Med 16:3004–3010, 2018). Previous studies report that microb...

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Autores principales: Zhao, Yue, Liu, Yuxia, Li, Shuang, Peng, Zhaoyun, Liu, Xiantao, Chen, Jun, Zheng, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236441/
https://www.ncbi.nlm.nih.gov/pubmed/34018055
http://dx.doi.org/10.1007/s00432-021-03644-0
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author Zhao, Yue
Liu, Yuxia
Li, Shuang
Peng, Zhaoyun
Liu, Xiantao
Chen, Jun
Zheng, Xin
author_facet Zhao, Yue
Liu, Yuxia
Li, Shuang
Peng, Zhaoyun
Liu, Xiantao
Chen, Jun
Zheng, Xin
author_sort Zhao, Yue
collection PubMed
description BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide (Ferlay et al., Int J Cancer 136:E359–386, 2015). In addition, lung cancer is associated with the highest mortality among all cancer types (Wu et al., Exp Ther Med 16:3004–3010, 2018). Previous studies report that microbiota play an important role in lung cancer. Notably, changes in lung and gut microbiota, are associated with progression of lung cancer. Several studies report that lung and gut microbiome promote lung cancer initiation and development by modulating metabolic pathways, inhibiting the function of immune cells, and producing pro-inflammatory factors. In addition, some factors such as microbiota dysbiosis, affect production of bacteriotoxins, genotoxicity and virulence effect, therefore, they play a key role in cancer progression. These findings imply that lung and gut microbiome are potential markers and targets for lung cancer. However, the role of microbiota in development and progression of lung cancer has not been fully explored. PURPOSE: The aim of this study was to systemically review recent research findings on relationship of lung and gut microbiota with lung cancer. In addition, we explored gut–lung axis and potential mechanisms of lung and gut microbiota in modulating lung cancer progression. CONCLUSION: Pulmonary and intestinal flora influence the occurrence, development, treatment and prognosis of lung cancer, and will provide novel strategies for prevention, diagnosis, and treatment of lung cancer.
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spelling pubmed-82364412021-07-09 Role of lung and gut microbiota on lung cancer pathogenesis Zhao, Yue Liu, Yuxia Li, Shuang Peng, Zhaoyun Liu, Xiantao Chen, Jun Zheng, Xin J Cancer Res Clin Oncol Review – Cancer Research BACKGROUND: Lung cancer is the leading cause of cancer-related deaths worldwide (Ferlay et al., Int J Cancer 136:E359–386, 2015). In addition, lung cancer is associated with the highest mortality among all cancer types (Wu et al., Exp Ther Med 16:3004–3010, 2018). Previous studies report that microbiota play an important role in lung cancer. Notably, changes in lung and gut microbiota, are associated with progression of lung cancer. Several studies report that lung and gut microbiome promote lung cancer initiation and development by modulating metabolic pathways, inhibiting the function of immune cells, and producing pro-inflammatory factors. In addition, some factors such as microbiota dysbiosis, affect production of bacteriotoxins, genotoxicity and virulence effect, therefore, they play a key role in cancer progression. These findings imply that lung and gut microbiome are potential markers and targets for lung cancer. However, the role of microbiota in development and progression of lung cancer has not been fully explored. PURPOSE: The aim of this study was to systemically review recent research findings on relationship of lung and gut microbiota with lung cancer. In addition, we explored gut–lung axis and potential mechanisms of lung and gut microbiota in modulating lung cancer progression. CONCLUSION: Pulmonary and intestinal flora influence the occurrence, development, treatment and prognosis of lung cancer, and will provide novel strategies for prevention, diagnosis, and treatment of lung cancer. Springer Berlin Heidelberg 2021-05-20 2021 /pmc/articles/PMC8236441/ /pubmed/34018055 http://dx.doi.org/10.1007/s00432-021-03644-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review – Cancer Research
Zhao, Yue
Liu, Yuxia
Li, Shuang
Peng, Zhaoyun
Liu, Xiantao
Chen, Jun
Zheng, Xin
Role of lung and gut microbiota on lung cancer pathogenesis
title Role of lung and gut microbiota on lung cancer pathogenesis
title_full Role of lung and gut microbiota on lung cancer pathogenesis
title_fullStr Role of lung and gut microbiota on lung cancer pathogenesis
title_full_unstemmed Role of lung and gut microbiota on lung cancer pathogenesis
title_short Role of lung and gut microbiota on lung cancer pathogenesis
title_sort role of lung and gut microbiota on lung cancer pathogenesis
topic Review – Cancer Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236441/
https://www.ncbi.nlm.nih.gov/pubmed/34018055
http://dx.doi.org/10.1007/s00432-021-03644-0
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