Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever

PURPOSE: Conditioning therapy with high-dose melphalan (HDM) is associated with a high risk of gut toxicity, fever and infections in haematopoietic stem cell transplant (HSCT) recipients. However, validated preclinical models that adequately reflect clinical features of melphalan-induced toxicity ar...

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Detalles Bibliográficos
Autores principales: Wardill, H. R., de Mooij, C. E. M., da Silva Ferreira, A. R., van de Peppel, I. P., Havinga, R., Harmsen, H. J. M., Tissing, W. J. E., Blijlevens, N. M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236460/
https://www.ncbi.nlm.nih.gov/pubmed/33877390
http://dx.doi.org/10.1007/s00280-021-04273-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236460/
https://www.ncbi.nlm.nih.gov/pubmed/33877390
http://dx.doi.org/10.1007/s00280-021-04273-7

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