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Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever
PURPOSE: Conditioning therapy with high-dose melphalan (HDM) is associated with a high risk of gut toxicity, fever and infections in haematopoietic stem cell transplant (HSCT) recipients. However, validated preclinical models that adequately reflect clinical features of melphalan-induced toxicity ar...
Autores principales: | Wardill, H. R., de Mooij, C. E. M., da Silva Ferreira, A. R., van de Peppel, I. P., Havinga, R., Harmsen, H. J. M., Tissing, W. J. E., Blijlevens, N. M. A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236460/ https://www.ncbi.nlm.nih.gov/pubmed/33877390 http://dx.doi.org/10.1007/s00280-021-04273-7 |
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