Lactate dehydrogenases amplify reactive oxygen species in cancer cells in response to oxidative stimuli

Previous studies demonstrated that superoxide could initiate and amplify LDH-catalyzed hydrogen peroxide production in aqueous phase, but its physiological relevance is unknown. Here we showed that LDHA and LDHB both exhibited hydrogen peroxide-producing activity, which was significantly enhanced by...

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Detalles Bibliográficos
Autores principales: Wu, Hao, Wang, Yuqi, Ying, Minfeng, Jin, Chengmeng, Li, Jiangtao, Hu, Xun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236487/
https://www.ncbi.nlm.nih.gov/pubmed/34176927
http://dx.doi.org/10.1038/s41392-021-00595-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236487/
https://www.ncbi.nlm.nih.gov/pubmed/34176927
http://dx.doi.org/10.1038/s41392-021-00595-3

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