De novo Design of G Protein-Coupled Receptor 40 Peptide Agonists for Type 2 Diabetes Mellitus Based on Artificial Intelligence and Site-Directed Mutagenesis

G protein-coupled receptor 40 (GPR40), one of the G protein-coupled receptors that are available to sense glucose metabolism, is an attractive target for the treatment of type 2 diabetes mellitus (T2DM). Despite many efforts having been made to discover small-molecule agonists, there is limited rese...

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Detalles Bibliográficos
Autores principales: Chen, Xu, Chen, Zhidong, Xu, Daiyun, Lyu, Yonghui, Li, Yongxiao, Li, Shengbin, Wang, Junqing, Wang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236607/
https://www.ncbi.nlm.nih.gov/pubmed/34195182
http://dx.doi.org/10.3389/fbioe.2021.694100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236607/
https://www.ncbi.nlm.nih.gov/pubmed/34195182
http://dx.doi.org/10.3389/fbioe.2021.694100

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