Fangchinoline Inhibits Human Esophageal Cancer by Transactivating ATF4 to Trigger Both Noxa-Dependent Intrinsic and DR5-Dependent Extrinsic Apoptosis

Esophageal squamous cell carcinoma (ESCC) is a recalcitrant cancer. The Chinese herbal monomer fangchinoline (FCL) has been reported to have anti-tumor activity in several human cancer cell types. However, the therapeutic efficacy and underlying mechanism on ESCC remain to be elucidated. In the pres...

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Detalles Bibliográficos
Autores principales: Zhang, Yunjing, Wang, Shiwen, Chen, Yukun, Zhang, Junqian, Yang, Jing, Xian, Jingrong, Li, Lihui, Zhao, Hu, Hoffman, Robert M., Zhang, Yanmei, Jia, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236818/
https://www.ncbi.nlm.nih.gov/pubmed/34195076
http://dx.doi.org/10.3389/fonc.2021.666549

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8236818/
https://www.ncbi.nlm.nih.gov/pubmed/34195076
http://dx.doi.org/10.3389/fonc.2021.666549

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