Pioglitazone Inhibits Diabetes-Induced Atrial Mitochondrial Oxidative Stress and Improves Mitochondrial Biogenesis, Dynamics, and Function Through the PPAR-γ/PGC-1α Signaling Pathway

Background: Oxidative stress contributes to adverse atrial remodeling in diabetes mellitus. This remodeling can be prevented by the PPAR-γ agonist pioglitazone via its antioxidant and anti-inflammatory effects. In this study, we examined the molecular mechanisms underlying the protective effects of...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Zhiwei, Zhang, Xiaowei, Meng, Lei, Gong, Mengqi, Li, Jian, Shi, Wen, Qiu, Jiuchun, Yang, Yajuan, Zhao, Jianping, Suo, Ya, Liang, Xue, Wang, Xinghua, Tse, Gary, Jiang, Ning, Li, Guangping, Zhao, Yungang, Liu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237088/
https://www.ncbi.nlm.nih.gov/pubmed/34194324
http://dx.doi.org/10.3389/fphar.2021.658362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237088/
https://www.ncbi.nlm.nih.gov/pubmed/34194324
http://dx.doi.org/10.3389/fphar.2021.658362

Ejemplares similares