Cargando…

Uncarboxylated osteocalcin promotes osteogenesis and inhibits adipogenesis of mouse bone marrow-derived mesenchymal stem cells via the PKA-AMPK-SIRT1 axis

Osteoporosis is a bone disease characterized by reduced bone density, thin cortical bone and large gaps in the bone's honeycomb structure, which increases the risk of bone fragility. Uncarboxylated osteocalcin (unOC), a vitamin K-dependent bone protein, is known to regulate carbohydrate and ene...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Le, Gong, Fang-Zi, Ma, Lu-Yao, Yang, Jian-Hong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237271/ https://www.ncbi.nlm.nih.gov/pubmed/34194558 http://dx.doi.org/10.3892/etm.2021.10312

Ejemplares similares

Uncarboxylated Osteocalcin Decreases SCD1 by Activating AMPK to Alleviate Hepatocyte Lipid Accumulation
por: Wang, Danqing, et al.
Publicado: (2023)

Smoking cessation increases levels of osteocalcin and uncarboxylated osteocalcin in human sera
por: Kiyota, Yasuhiro, et al.
Publicado: (2020)

Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow–derived mesenchymal stem cells by regulating TP63
por: Gong, Fangzi, et al.
Publicado: (2021)

Uncarboxylated Osteocalcin Induces Antitumor Immunity against Mouse Melanoma Cell Growth
por: Hayashi, Yoshikazu, et al.
Publicado: (2017)

Differential Roles of Carboxylated and Uncarboxylated Osteocalcin in Prostate Cancer Growth
por: Hayashi, Yoshikazu, et al.
Publicado: (2016)

Assessment of Uncarboxylated Osteocalcin Levels in Type 2 Diabetes Mellitus
por: Alamri, Taghreed M, et al.
Publicado: (2023)

Elevated Creatine Kinase and Lactic Acid Dehydrogenase and Decreased Osteocalcin and Uncarboxylated Osteocalcin are Associated with Bone Stress Injuries in Young Female Athletes
por: Miyamoto, Takeshi, et al.
Publicado: (2018)

Association between serum uncarboxylated osteocalcin levels and nutritional intake in Japanese female athletes
por: Ishizu, Tatsuya, et al.
Publicado: (2022)

Recombinant Antibodies with Unique Specificities Allow for Sensitive and Specific Detection of Uncarboxylated Osteocalcin in Human Circulation
por: Arponen, Milja, et al.
Publicado: (2020)

Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow
por: Song, Jie, et al.
Publicado: (2019)

Recombinant Uncarboxylated Osteocalcin Per Se Enhances Mouse Skeletal Muscle Glucose Uptake in both Extensor Digitorum Longus and Soleus Muscles
por: Lin, Xuzhu, et al.
Publicado: (2017)

Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway
por: Zhang, Xiao-lin, et al.
Publicado: (2019)

Melatonin suppresses bone marrow adiposity in ovariectomized rats by rescuing the imbalance between osteogenesis and adipogenesis through SIRT1 activation
por: Huang, Xiaoxiong, et al.
Publicado: (2022)

Regulation of base excision repair during adipogenesis and osteogenesis of bone marrow-derived mesenchymal stem cells
por: Kim, Min, et al.
Publicado: (2023)

Bone Marrow and Adipose Tissue Adenosine Receptors Effect on Osteogenesis and Adipogenesis
por: Eisenstein, Anna, et al.
Publicado: (2020)

Uncarboxylated osteocalcin promotes proliferation and metastasis of MDA-MB-231 cells through TGF-β/SMAD3 signaling pathway
por: Xu, Jiaojiao, et al.
Publicado: (2022)

cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin
por: Yang, Der-Chih, et al.
Publicado: (2008)

Oncostatin M Maintains the Hematopoietic Microenvironment in the Bone Marrow by Modulating Adipogenesis and Osteogenesis
por: Sato, Fumi, et al.
Publicado: (2014)

A Reciprocal Role of the Smad4‐Taz Axis in Osteogenesis and Adipogenesis of Mesenchymal Stem Cells
por: Park, Jin Seok, et al.
Publicado: (2018)

MiRNA-320a-5p contributes to the homeostasis of osteogenesis and adipogenesis in bone marrow mesenchymal stem cell
por: Zhang, Ying, et al.
Publicado: (2022)

Roles of MicroRNAs in Osteogenesis or Adipogenesis Differentiation of Bone Marrow Stromal Progenitor Cells
por: Zhang, Ya-Li, et al.
Publicado: (2021)

Acoustic-Frequency Vibratory Stimulation Regulates the Balance between Osteogenesis and Adipogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells
por: Chen, Xi, et al.
Publicado: (2015)

Functional differences of Toll‐like receptor 4 in osteogenesis, adipogenesis and chondrogenesis in human bone marrow‐derived mesenchymal stem cells
por: Khodabandehloo, Fatemeh, et al.
Publicado: (2021)

Dracunculin Inhibits Adipogenesis in Human Bone Marrow-Derived Mesenchymal Stromal Cells by Activating AMPK and Wnt/β-Catenin Signaling
por: Karadeniz, Fatih, et al.
Publicado: (2022)

Reciprocal Effect of Environmental Stimuli to Regulate the Adipogenesis and Osteogenesis Fate Decision in Bone Marrow-Derived Mesenchymal Stem Cells (BM-MSCs)
por: Xu, Xinyun, et al.
Publicado: (2023)

Osteogenesis of bone marrow mesenchymal stem cell in hyperglycemia
por: Luo, Meng, et al.
Publicado: (2023)

Melatonin alleviates oxidative stress-inhibited osteogenesis of human bone marrow-derived mesenchymal stem cells through AMPK activation
por: Lee, Sooho, et al.
Publicado: (2018)

Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway
por: Ruan, Banjun, et al.
Publicado: (2018)

The Effects of Endocrine Disruptors on Adipogenesis and Osteogenesis in Mesenchymal Stem Cells: A Review
por: Bateman, Marjorie E., et al.
Publicado: (2017)

Emodin enhances osteogenesis and inhibits adipogenesis
por: Yang, Feng, et al.
Publicado: (2014)

HSPB7 oppositely regulates human mesenchymal stromal cell-derived osteogenesis and adipogenesis
por: Zhang, Shuang, et al.
Publicado: (2023)

Functional differences between AMPK α1 and α2 subunits in osteogenesis, osteoblast-associated induction of osteoclastogenesis, and adipogenesis
por: Wang, Yu-gang, et al.
Publicado: (2016)

Inhibition of Y1 Receptor Promotes Osteogenesis in Bone Marrow Stromal Cells via cAMP/PKA/CREB Pathway
por: Yu, Wei, et al.
Publicado: (2020)

Puerarin promotes osteogenesis and inhibits adipogenesis in vitro
por: Wang, Nan, et al.
Publicado: (2013)

Retraction Note: Azoramide, a novel regulator, favors adipogenesis against osteogenesis through inhibiting the GLP-1 receptor-PKA-β-catenin pathway
por: Ruan, Banjun, et al.
Publicado: (2023)

Comparison of gingiva‐derived and bone marrow mesenchymal stem cells for osteogenesis
por: Sun, Quan, et al.
Publicado: (2019)

The role of osteocalcin in regulation of glycolipid metabolism and muscle function in children with osteogenesis imperfecta
por: Zheng, Wen-bin, et al.
Publicado: (2022)

Sirt7 promotes adipogenesis by binding to and inhibiting Sirt1
por: Bober, Eva, et al.
Publicado: (2012)

The role of microRNAs in cell fate determination of mesenchymal stem cells : balancing adipogenesis and osteogenesis
por: Kang, Hara, et al.
Publicado: (2015)

Adipogenesis, Osteogenesis, and Chondrogenesis of Human Mesenchymal Stem/Stromal Cells: A Comparative Transcriptome Approach
por: Robert, Anny W., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_39cfhlv7llu9vjphkd0lf16mt2