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Dental effects of enzyme replacement therapy in case of childhood-type hypophosphatasia

BACKGROUND: Hypophosphatasia (HPP), a skeletal disease characterized by hypomineralization of bone and teeth, is caused by an ALPL gene mutation that leads to low activity of the tissue non-specific alkaline phosphatase enzyme. Although enzyme replacement therapy (ERT) was recently introduced for af...

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Detalles Bibliográficos
Autores principales: Okawa, Rena, Kokomoto, Kazuma, Nakano, Kazuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237502/
https://www.ncbi.nlm.nih.gov/pubmed/34176466
http://dx.doi.org/10.1186/s12903-021-01673-2