Preclinical in vitro and in vivo profile of a highly-attenuated, broadly efficacious pneumolysin genetic toxoid

Pneumolysin is a highly conserved, cholesterol-dependent cytolysin that is an important Streptococcus pneumoniae virulence factor and an attractive target for vaccine development. To attenuate pneumolysin toxicity, a genetic toxoid was constructed with two amino acid changes, G293S and L460D, termed...

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Detalles Bibliográficos
Autores principales: Thanawastien, Ann, Joyce, Kelsey E., Cartee, Robert T., Haines, Laurel A., Pelton, Stephen I., Tweten, Rodney K., Killeen, Kevin P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237519/
https://www.ncbi.nlm.nih.gov/pubmed/32532546
http://dx.doi.org/10.1016/j.vaccine.2020.04.064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237519/
https://www.ncbi.nlm.nih.gov/pubmed/32532546
http://dx.doi.org/10.1016/j.vaccine.2020.04.064

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