Fever supports CD8(+) effector T cell responses by promoting mitochondrial translation

Fever can provide a survival advantage during infection. Metabolic processes are sensitive to environmental conditions, but the effect of fever on T cell metabolism is not well characterized. We show that in activated CD8(+) T cells, exposure to febrile temperature (39 °C) augmented metabolic activi...

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Detalles Bibliográficos
Autores principales: O’Sullivan, David, Stanczak, Michal A., Villa, Matteo, Uhl, Franziska M., Corrado, Mauro, Klein Geltink, Ramon I., Sanin, David E., Apostolova, Petya, Rana, Nisha, Edwards-Hicks, Joy, Grzes, Katarzyna M., Kabat, Agnieszka M., Kyle, Ryan L., Fabri, Mario, Curtis, Jonathan D., Buck, Michael D., Patterson, Annette E., Regina, Annamaria, Field, Cameron S., Baixauli, Francesc, Puleston, Daniel J., Pearce, Edward J., Zeiser, Robert, Pearce, Erika L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237659/
https://www.ncbi.nlm.nih.gov/pubmed/34161266
http://dx.doi.org/10.1073/pnas.2023752118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237659/
https://www.ncbi.nlm.nih.gov/pubmed/34161266
http://dx.doi.org/10.1073/pnas.2023752118

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