PSD-95 protects synapses from β-amyloid

Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, a major synaptic scaffolding molecule, blocks the effects of Aβ on synapses. The protective effect persists in tissue lacking the AMPA recep...

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Detalles Bibliográficos
Autores principales: Dore, Kim, Carrico, Zachary, Alfonso, Stephanie, Marino, Marc, Koymans, Karin, Kessels, Helmut W., Malinow, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237704/
https://www.ncbi.nlm.nih.gov/pubmed/34077732
http://dx.doi.org/10.1016/j.celrep.2021.109194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237704/
https://www.ncbi.nlm.nih.gov/pubmed/34077732
http://dx.doi.org/10.1016/j.celrep.2021.109194

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