Cargando…

PSD-95 protects synapses from β-amyloid

Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, a major synaptic scaffolding molecule, blocks the effects of Aβ on synapses. The protective effect persists in tissue lacking the AMPA recep...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dore, Kim, Carrico, Zachary, Alfonso, Stephanie, Marino, Marc, Koymans, Karin, Kessels, Helmut W., Malinow, Roberto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8237704/ https://www.ncbi.nlm.nih.gov/pubmed/34077732 http://dx.doi.org/10.1016/j.celrep.2021.109194

Ejemplares similares

Excitation Control: Balancing PSD-95 Function at the Synapse
por: Keith, Dove, et al.
Publicado: (2008)

A fluorescence assay for detecting amyloid-β using the cytomegalovirus enhancer/promoter
por: Carrico, Zachary M., et al.
Publicado: (2017)

Acute Inactivation of PSD-95 Destabilizes AMPA Receptors at Hippocampal Synapses
por: Yudowski, Guillermo A., et al.
Publicado: (2013)

D-Serine and Serine Racemase Are Associated with PSD-95 and Glutamatergic Synapse Stability
por: Lin, Hong, et al.
Publicado: (2016)

Chemical shift assignments of the N-terminal domain of PSD95 (PSD95-NT)
por: Zhang, Yonghong, et al.
Publicado: (2021)

Pin1 Binding to Phosphorylated PSD-95 Regulates the Number of Functional Excitatory Synapses
por: Delgado, Jary Y., et al.
Publicado: (2020)

CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment
por: Subramanian, Jaichandar, et al.
Publicado: (2019)

Multiple axons and actions with PSD-95
por: Williams, Ruth
Publicado: (2008)

Durable fear memories require PSD-95
por: Fitzgerald, Paul J., et al.
Publicado: (2014)

FMRP: a triple threat to PSD-95
por: Westmark, Cara J.
Publicado: (2013)

Spine dynamics of PSD-95-deficient neurons in the visual cortex link silent synapses to structural cortical plasticity
por: Yusifov, Rashad, et al.
Publicado: (2021)

Vasopressin acts as a synapse organizer in limbic regions by boosting PSD95 and GluA1 expression
por: Zhang, Limei, et al.
Publicado: (2022)

Cytosolic PSD-95 interactor alters functional organization of neural circuits and AMPA receptor signaling independent of PSD-95 binding
por: Rodriguez, Ana R., et al.
Publicado: (2021)

Rapid Redistribution of Synaptic PSD-95 in the Neocortex In Vivo
por: Gray, Noah W, et al.
Publicado: (2006)

Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions
por: Yoo, Ki-Seo, et al.
Publicado: (2019)

Distinct SAP102 and PSD-95 nano-organization defines multiple types of synaptic scaffold protein domains at single synapses
por: Metzbower, Sarah R., et al.
Publicado: (2023)

A closer look at the synapse: dlg1[4K] enables cell-specific visualization of PSD-95/DLG1
por: Hendricks, Emily L., et al.
Publicado: (2023)

Structural Modeling of Protein Interactions by Analogy: Application to PSD-95
por: Korkin, Dmitry, et al.
Publicado: (2006)

Clustering of neuronal potassium channels is independent of their interaction with PSD-95
por: Rasband, Matthew N., et al.
Publicado: (2002)

Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
por: Cao, Cong, et al.
Publicado: (2013)

PSD95 nanoclusters are postsynaptic building blocks in hippocampus circuits
por: Broadhead, Matthew J., et al.
Publicado: (2016)

Neurodevelopmental Disorders Associated with PSD-95 and Its Interaction Partners
por: Levy, Amanda M., et al.
Publicado: (2022)

Distinct Structural Requirements for Clustering and Immobilization of K(+) Channels by PSD-95
por: Burke, Nancy A., et al.
Publicado: (1999)

Correction: Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
Publicado: (2014)

Correction: Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome
por: Cao, Cong, et al.
Publicado: (2013)

Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes
por: Frank, René A. W., et al.
Publicado: (2017)

Non-genomic mechanisms mediate androgen-induced PSD95 expression
por: Zhang, Yizhou, et al.
Publicado: (2019)

Anchoring and Synaptic stability of PSD-95 is driven by ephrin-B3
por: Hruska, Martin, et al.
Publicado: (2015)

PSD-95 Serine 73 phosphorylation is not required for induction of NMDA-LTD
por: Nowacka, Agata, et al.
Publicado: (2020)

PSD-95: An Effective Target for Stroke Therapy Using Neuroprotective Peptides
por: Ugalde-Triviño, Lola, et al.
Publicado: (2021)

Long-term potentiation reconstituted with an artificial TARP/PSD-95 complex
por: Ravi, Anagh Sinha, et al.
Publicado: (2022)

Fuzzy supertertiary interactions within PSD-95 enable ligand binding
por: Hamilton, George L, et al.
Publicado: (2022)

PDI-Mediated Reduction of Disulfide Bond on PSD95 Increases Spontaneous Seizure Activity by Regulating NR2A–PSD95 Interaction in Epileptic Rats Independent of S-Nitrosylation
por: Lee, Duk-Shin, et al.
Publicado: (2020)

Tau induces PSD95-nNOS uncoupling and neurovascular dysfunction independent of neurodegeneration
por: Park, Laibaik, et al.
Publicado: (2020)

FRET-FLIM Investigation of PSD95-NMDA Receptor Interaction in Dendritic Spines; Control by Calpain, CaMKII and Src Family Kinase
por: Doré, Kim, et al.
Publicado: (2014)

Ocular Dominance Plasticity after Stroke Was Preserved in PSD-95 Knockout Mice
por: Greifzu, Franziska, et al.
Publicado: (2016)

PTBP-dependent PSD-95 and CamKIIα alternative splicing in the lens
por: Frederikse, Peter, et al.
Publicado: (2014)

Identification of PSD-95 in the Postsynaptic Density Using MiniSOG and EM Tomography
por: Chen, Xiaobing, et al.
Publicado: (2018)

PSD-95 deficiency disrupts PFC-associated function and behavior during neurodevelopment
por: Coley, Austin A., et al.
Publicado: (2019)

Human Serine Racemase Weakly Binds the Third PDZ Domain of PSD-95
por: Giaccari, Roberta, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s87l55h401dm8b2fto9dpd5j2e