Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints

We describe an approach for integrating distance restraints from Double Electron-Electron Resonance (DEER) spectroscopy into Rosetta with the purpose of modeling alternative protein conformations from an initial experimental structure. Fundamental to this approach is a multilateration algorithm that...

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Detalles Bibliográficos
Autores principales: del Alamo, Diego, Jagessar, Kevin L., Meiler, Jens, Mchaourab, Hassane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238229/
https://www.ncbi.nlm.nih.gov/pubmed/34133419
http://dx.doi.org/10.1371/journal.pcbi.1009107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238229/
https://www.ncbi.nlm.nih.gov/pubmed/34133419
http://dx.doi.org/10.1371/journal.pcbi.1009107

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