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Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints
We describe an approach for integrating distance restraints from Double Electron-Electron Resonance (DEER) spectroscopy into Rosetta with the purpose of modeling alternative protein conformations from an initial experimental structure. Fundamental to this approach is a multilateration algorithm that...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238229/ https://www.ncbi.nlm.nih.gov/pubmed/34133419 http://dx.doi.org/10.1371/journal.pcbi.1009107 |