Cancer-epigenetic function of the histone methyltransferase KMT2D and therapeutic opportunities for the treatment of KMT2D-deficient tumors

Epigenetic mechanisms are central to understanding the molecular basis underlying tumorigenesis. Aberrations in epigenetic modifiers alter epigenomic landscapes and play a critical role in tumorigenesis. Notably, the histone lysine methyltransferase KMT2D (a COMPASS/ Set1 family member; also known a...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhar, Shilpa S., Lee, Min Gyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238240/
https://www.ncbi.nlm.nih.gov/pubmed/34194626
http://dx.doi.org/10.18632/oncotarget.27988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238240/
https://www.ncbi.nlm.nih.gov/pubmed/34194626
http://dx.doi.org/10.18632/oncotarget.27988

Ejemplares similares