TERT and its binding protein: overexpression of GABPA/B in high grade gliomas

Enhanced expression of TERT in gliomas is a result of two hotspot mutations, C228T and C250T, at the promoter region. GA-binding proteins selectively bind at these positions, respectively, causing an activation of the promoter and overexpression of TERT. GABP is a multimeric protein consisting of GA...

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Detalles Bibliográficos
Autores principales: Papazacharias, Efthymios, Kuhl, Saskia, Röhn, Gabriele, Görtz, Lukas, Goldbrunner, Roland, Timmer, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2021
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238242/
https://www.ncbi.nlm.nih.gov/pubmed/34194624
http://dx.doi.org/10.18632/oncotarget.27985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238242/
https://www.ncbi.nlm.nih.gov/pubmed/34194624
http://dx.doi.org/10.18632/oncotarget.27985

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