Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2

Coronaviruses, like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), encode a nucleotidyl transferase in the N-terminal (NiRAN) domain of the nonstructural protein (nsp) 12 protein within the RNA dependent RNA polymerase. Here we show the detection of guanosine monophosphate (GMP) and u...

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Detalles Bibliográficos
Autores principales: Conti, Brian J., Leicht, Andrew S., Kirchdoerfer, Robert N., Sussman, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238455/
https://www.ncbi.nlm.nih.gov/pubmed/34189273
http://dx.doi.org/10.1038/s42004-021-00476-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238455/
https://www.ncbi.nlm.nih.gov/pubmed/34189273
http://dx.doi.org/10.1038/s42004-021-00476-4

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