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Mass spectrometric based detection of protein nucleotidylation in the RNA polymerase of SARS-CoV-2
Coronaviruses, like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), encode a nucleotidyl transferase in the N-terminal (NiRAN) domain of the nonstructural protein (nsp) 12 protein within the RNA dependent RNA polymerase. Here we show the detection of guanosine monophosphate (GMP) and u...
Autores principales: | Conti, Brian J., Leicht, Andrew S., Kirchdoerfer, Robert N., Sussman, Michael R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238455/ https://www.ncbi.nlm.nih.gov/pubmed/34189273 http://dx.doi.org/10.1038/s42004-021-00476-4 |
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