Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption

Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may represent a promising new class of bone anabolic agents. H...

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Detalles Bibliográficos
Autores principales: Tang, Cheng-Chia, Castro Andrade, Christian D, O'Meara, Maureen J, Yoon, Sung-Hee, Sato, Tadatoshi, Brooks, Daniel J, Bouxsein, Mary L, Martins, Janaina da Silva, Wang, Jinhua, Gray, Nathanael S, Misof, Barbara, Roschger, Paul, Blouin, Stephane, Klaushofer, Klaus, Velduis-Vlug, Annegreet, Vegting, Yosta, Rosen, Clifford J, O'Connell, Daniel, Sundberg, Thomas B, Xavier, Ramnik J, Ung, Peter, Schlessinger, Avner, Kronenberg, Henry M, Berdeaux, Rebecca, Foretz, Marc, Wein, Marc N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238509/
https://www.ncbi.nlm.nih.gov/pubmed/34160349
http://dx.doi.org/10.7554/eLife.67772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238509/
https://www.ncbi.nlm.nih.gov/pubmed/34160349
http://dx.doi.org/10.7554/eLife.67772

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