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Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption
Bone formation and resorption are typically coupled, such that the efficacy of anabolic osteoporosis treatments may be limited by bone destruction. The multi-kinase inhibitor YKL-05–099 potently inhibits salt inducible kinases (SIKs) and may represent a promising new class of bone anabolic agents. H...
Autores principales: | Tang, Cheng-Chia, Castro Andrade, Christian D, O'Meara, Maureen J, Yoon, Sung-Hee, Sato, Tadatoshi, Brooks, Daniel J, Bouxsein, Mary L, Martins, Janaina da Silva, Wang, Jinhua, Gray, Nathanael S, Misof, Barbara, Roschger, Paul, Blouin, Stephane, Klaushofer, Klaus, Velduis-Vlug, Annegreet, Vegting, Yosta, Rosen, Clifford J, O'Connell, Daniel, Sundberg, Thomas B, Xavier, Ramnik J, Ung, Peter, Schlessinger, Avner, Kronenberg, Henry M, Berdeaux, Rebecca, Foretz, Marc, Wein, Marc N |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238509/ https://www.ncbi.nlm.nih.gov/pubmed/34160349 http://dx.doi.org/10.7554/eLife.67772 |
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