Dependency of human and murine LKB1-inactivated lung cancer on aberrant CRTC-CREB activation

Lung cancer with loss-of-function of the LKB1 tumor suppressor is a common aggressive subgroup with no effective therapies. LKB1-deficiency induces constitutive activation of cAMP/CREB-mediated transcription by a family of three CREB-regulated transcription coactivators (CRTC1-3). However, the signi...

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Detalles Bibliográficos
Autores principales: Zhou, Xin, Li, Jennifer W, Chen, Zirong, Ni, Wei, Li, Xuehui, Yang, Rongqiang, Shen, Huangxuan, Liu, Jian, DeMayo, Francesco J, Lu, Jianrong, Kaye, Frederic J, Wu, Lizi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238510/
https://www.ncbi.nlm.nih.gov/pubmed/34142658
http://dx.doi.org/10.7554/eLife.66095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238510/
https://www.ncbi.nlm.nih.gov/pubmed/34142658
http://dx.doi.org/10.7554/eLife.66095

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