Small molecule inhibitors targeting Polycomb Repressive Complex 1 RING domain

Polycomb repressive complex 1 (PRC1) is an essential chromatin modifying complex that monoubiquitinates histone H2A and is involved in maintaining the repressed chromatin state. Emerging evidence suggests PRC1 activity in various cancers, rationalizing the need for small molecule inhibitors with a w...

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Detalles Bibliográficos
Autores principales: Shukla, Shirish, Ying, Weijiang, Gray, Felicia, Yao, Yiwu, Simes, Miranda L., Zhao, Qingjie, Miao, Hongzhi, Cho, Hyo Je, González-Alonso, Paula, Winkler, Alyssa, Lund, George, Purohit, Trupta, Kim, EunGi, Zhang, Xiaotian, Ray, Joshua M., He, Shihan, Nikolaidis, Caroline, Ndoj, Juliano, Wang, Jingya, Jaremko, Łukasz, Jaremko, Mariusz, Ryan, Russell J.H., Guzman, Monica L., Grembecka, Jolanta, Cierpicki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238916/
https://www.ncbi.nlm.nih.gov/pubmed/34155404
http://dx.doi.org/10.1038/s41589-021-00815-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238916/
https://www.ncbi.nlm.nih.gov/pubmed/34155404
http://dx.doi.org/10.1038/s41589-021-00815-5

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