Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors

We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN) biosensors, to detect spontaneous pre-fibrillar oligomers in living cells. Our two αSN FRET biosensors provide complementary insight into αSN ol...

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Detalles Bibliográficos
Autores principales: Braun, Anthony R., Liao, Elly E., Horvath, Mian, Kalra, Prakriti, Acosta, Karen, Young, Malaney C., Kochen, Noah Nathan, Lo, Chih Hung, Brown, Roland, Evans, Michael D., Pomerantz, William C. K., Rhoades, Elizabeth, Luk, Kelvin, Cornea, Razvan L., Thomas, David D., Sachs, Jonathan N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238948/
https://www.ncbi.nlm.nih.gov/pubmed/34183676
http://dx.doi.org/10.1038/s41531-021-00195-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8238948/
https://www.ncbi.nlm.nih.gov/pubmed/34183676
http://dx.doi.org/10.1038/s41531-021-00195-6

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